Tooth extraction is a common surgical procedure in dental medicine. In a study published in the International Journal of Molecular Sciences, researchers from Tokyo Medical and Dental University (TMDU) have revealed that a gene delivery therapy can effectively suppress inflammation to enhance tissue healing after tooth extraction. That wish may come true now that a research team has developed a polymeric gene delivery therapy that promotes new bone formation after traumatic inflammation. Credit: Department of Orthodontic Science, TMDUĭoes a "magic bullet" exist in regenerative medicine? Researchers have long wished to design a cutting-edge gene therapy that regenerates tissues damaged by disease or trauma. PLGA-NfD demonstrates inhibitory effect on osteoclast differentiation and inflammatory cells (Upper), including the reduction of alveolar bone resorption, thereby allowing the continuing dynamic healing potential to accelerate new bone formation in the extraction socket, as assessed by bone-labeling technique with calcein (green), demeclocycline hydrochloride (yellow), and alizarin complexone (red) (Lower).Abbreviations: NfD, naked NF-κB decoy NF-κB, nuclear factor-kappa B ODN, oligodeoxynucleotide PBS, phosphate-buffered saline PLGA, poly(lactic-co-glycolic acid) PLGA-NfD, NF-κB decoy ODN-loaded PLGA nanosphere PLGA-ScD, scrambled decoy ODN-loaded PLGA nanosphere ScD, naked scrambled decoy. Prophylactic treatment of NF-κB decoy ODN-loaded PLGA nanospheres local administration prevents alveolar bone loss and promotes wound healing after tooth extraction.
0 kommentar(er)
